2027 Summer Intern - Translational Safety (Computational Toxicology)

Roche

South San Francisco · Posted 10h ago

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At a glance

Location: South San Francisco, United States
Work type: Onsite
Category: Research

2027 Summer Intern - Translational Safety (Computational Toxicology) at Roche in South San Francisco. Full-time paid 12-week internship (May/June 2027 – August/September 2027) focusing on evaluating how well in vitro bioactivity screens predict clinical adverse events using R, with opportunities to incorporate public datasets. On-site role in the Computational Toxicology group under Translational Safety.

What they are looking for

RToxicologyIn_vitro_in_vivo_toxicologyMachine_learningCommunication

Location: South San Francisco

2027 Summer Intern - Translational Safety (Computational Toxicology)

Department Summary

Development Sciences (DevSci) spans the entire drug discovery and development cycle—from early-stage research to drug commercialization. Part of the drug development pipeline in DevSci includes the preclinical safety evaluation of candidate therapeutic molecules by toxicologists and pathologists in the Translational Safety (TS) department in order to enable further evaluation in humans. Translational Safety is an integral part of DevSci. We contribute to the organization’s success by providing scientific insights and ensuring the safety of molecules that advance through the pipeline to patients. We do this to support the DevSci vision to deliver the right drug in the right dose to the right patient. We are also committed to providing better outcomes for our people, patients, business, and communities by advancing and boldly championing diversity, equity, and inclusion in our work.

Translational Safety’s Vision: We revolutionize and accelerate drug development through cutting-edge predictive, translational sciences.

Translational Safety’s Mission: We develop transformative therapeutics for patients by delivering rigorous translational strategies and model-informed predictive insights for all therapeutic modalities through the entire drug development lifecycle via innovative experimental and computational approaches.

The Translational Safety organization is composed of several integrated sub-functions. This summer intern project falls within the Computational Toxicology sub-function. The Computational Toxicology group enables early and accurate compound safety profiling by leveraging all relevant data (in vitro, ex vivo, in vivo, and clinical), advanced analytics, and computational modeling while closely collaborating with other Translational Safety groups such as Investigative Toxicology and Complex In Vitro Systems (CiS).

This internship position is located in South San Francisco, on-site.

The Opportunity

The Computational Toxicology group is seeking a talented and motivated summer intern with a strong foundation in toxicology to expand the predictive capabilities of our translational safety data platforms. A central challenge in preclinical drug safety is understanding how effectively early in vitro screening assays translate to human clinical safety outcomes, and identifying which toxicological liabilities our current screening suites fail to capture.

This project will focus primarily on evaluating how well internal in vitro bioactivity screening assays predict clinical adverse drug reactions (ADRs), using machine learning and statistical modeling frameworks built in R. As a secondary objective, the project will assess whether incorporating public in vitro bioactivity datasets can capture safety signals that internal assays may overlook.

The intern will directly drive

Data Curation & Harmonization: Ingesting, cleaning, and standardizing internal in vitro screening readouts alongside clinical safety and adverse event data, with targeted integration of relevant public bioactivity datasets as needed.

Translational Benchmarking & Predictive Modeling: Applying statistical frameworks and machine learning techniques in R to correlate in vitro bioactivity profiles with observed clinical adverse events across target organ systems (e.g., drug-induced liver injury, cardiovascular findings).

Assay Concordance & Gap Analysis: Evaluating the sensitivity and predictive limits of our internal screening battery against clinical outcomes, exploring whether complementary public assay data can fill specific translational blind spots.

Ultimately, these insights will directly inform the translational utility of our current screening battery, highlighting actionable avenues to guide future in-house in vitro assay development and build more robust machine learning models for early predictive toxicology.

Key Responsibilities

Extract, clean, and harmonize clinical trial safety data and adverse event findings across internal and external clinical datasets for target chemical space.

Aggregate, curate, and standardize high-throughput in vitro bioactivity screening data from internal discovery databases, incorporating relevant public bioactivity data where appropriate.

Integrate curated in vitro and clinical safety datasets into internal translational safety data platforms using R.

Develop, apply, and evaluate machine learning models and statistical benchmarking workflows in R to determine how reliably early assay readouts predict human clinical adverse events.

Perform translational gap analyses to characterize which clinical toxicities are well-predicted by current screening batteries versus those that require new or complementary assay strategies.

Synthesize findings and support data-driven recommendations on assay performance and future predictive toxicology strategies to computational toxicologists, discovery toxicologists, and cross-functional teams.