Research Assistant II

Location: Boston, MA, us Department: Harvard Program in Therapeutic Science Employment Type: {'id': 'permanent', 'label': 'Full-time'}

Company Description

By working at Harvard University, you join a vibrant community that advances Harvard's world-changing mission in meaningful ways, inspires innovation and collaboration, and builds skills and expertise. We are dedicated to creating a diverse and welcoming environment where everyone can thrive.

Why join Harvard Medical School?

Harvard Medical School's mission is to nurture a diverse, inclusive community dedicated to alleviating suffering and improving health and well-being for all through excellence in teaching and learning, discovery and scholarship, and service and leadership.

You’ll be at the heart of biomedical discovery, education, and innovation, working alongside world-renowned faculty and a community dedicated to improving human health. This is more than a job - it’s an opportunity to shape the future of medicine.

About the Harvard Program in Therapeutic Science

The Laboratory of Systems Pharmacology Tissue Profiling Service (LSP-TPS) Core Facility within the Harvard Program in Therapeutic Science at Harvard Medical School is seeking a Research Assistant II to join an interdisciplinary team of biomedical scientists and software engineers. Our team is dedicated to advancing the science needed for precision medicine approaches to drug discovery and patient care. The Core provides services to scientists and clinicians in the Boston area and beyond, providing access to innovative methods for studying human tissues and biopsies. These include cutting-edge spatial biology methods that provide unique insight into the molecular features of healthy and diseased tissues. These assays include multiplexed cyclic immunofluorescence and GeoMx Digital Spatial Profiling (DSP).

Job Description

Under the supervision of the LSP-TPS core director, the Research Assistant II will learn and perform spatial profiling assays on samples from human patients and model organisms. This position also offers the opportunity to learn how to process the resulting data using AI tools. The LSP-TPS Core is an intense and collaborative environment that handles clinical samples that are precious and difficult to replace. Thus, the successful candidate must be organized and detail-oriented, possess strong reasoning and communication skills, and excel at working in teams.

Job-Specific Responsibilities

Perform CycIF, ORION, and GeoMX profiling assays following established protocols, such as:

Immunofluorescence staining of samples on slides o Image slides using a variety of fluorescence- and brightfield-based microscopes and scanners.

Prepare and submit libraries for Next Generation Sequencing (NGS).

Perform quality control testing of antibodies and other reagents.

Once trained, instruct core users in routine spatial profiling workflows.

Collect, process, and summarize experimental data for core users.

Maintain an electronic lab notebook and keep detailed, accurate, up-to-date records of all experiments.

Create and update written protocols; collaborate to optimize experimental design and protocols; help draft scientific written reports.

Maintain common lab supplies, equipment, and glass slide inventories; interface with vendor and service representatives.

Help process core invoices and perform other simple clerical duties under the direction of senior core personnel.

As part of your application, we recommend including a cover letter that will help us better understand your qualifications and background. This can provide valuable insight into your experience and interest in the role.

Physical Requirements

Must be comfortable working in a lab environment and working with sensitive lab equipment and samples.

Qualifications

Basic Qualifications

College background or equivalent work experience in Biological Sciences, Biomedical Engineering, or related discipline.

One or more years related work experience in a laboratory setting (relevant laboratory course work may count towards experience).

Additional Qualifications and Skills

Bachelor's degree in Biological Sciences, Engineering or related discipline.

Demonstrated abilities in molecular biology techniques are required.

Experience with fluorescence microscopy, image analysis, and antibody-based detection is preferred.

Must possess keen attention to detail and exceptional organizational skills.

Motivated self-starter, quick learner, with strong problem-solving abilities required.

Familiarity with drafting protocols and presenting scientific results using common computer programs (e.g., MS Word, Excel, PowerPoint).

Strong written and spoken English skills.

Strong interpersonal communication skills with high capacity to work both independently and in teams.

Programming knowledge is a plus.

May be required to work with a variety of hazardous materials and enclosed Class 3B lasers.

Additional Information

Term: This is a term position, with an end date of 31-OCT-2027, with the possibility of extension, contingent upon work performance and continued funding to support the position.

Standard Hours/Schedule: 35 hrs. per week | Monday - Friday | 9:00 am - 5:00 pm. This position is considered to be essential personnel for the Harvard Program in Therapeutic. Weekend and holiday work may be required as well as attendance during school closures (due to inclement weather and/or other emergencies).

Visa Sponsorship Information: Harvard University is unable to provide visa sponsorship for this position

Pre-Employment Screening: Identity

Staying Informed About Your Application: Due to the high volume of applications, we may not always be able to reach out right away, but you can track your status anytime through the Careers@Harvard portal.

Interview Format: The interview process will include both virtual and in-person components (e.g., initial virtual screening followed by on-campus final intervi