Research Fellow (DMOAJ)

Singhealth

Singapore · Posted Oct 12

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At a glance

Location: Singapore, Singapore
Work type: Onsite
Category: Research

Research Fellow position in translational immuno-oncology focused on developing bispecific therapeutic strategies for lung cancer. Responsibilities include designing and executing in vitro and in vivo studies, working with lung cancer cell lines, organoids, and human immune cells, performing functional assays and flow cytometry, and contributing to translational strategy and publications.

What they are looking for

Cancer immunologyBispecific/antibody therapeuticsT-cell biologyFlow cytometryIn vivo tumor models

Location: Singapore, Sing, SG

National Cancer Centre of Singapore Pte Ltd

Research Fellow (DMOAJ)

Job Category

Research

Posting Date

12 Oct 2026

We are seeking a highly motivated Research Fellow to join our translational immuno-oncologyteam developing bispecific therapeutic strategies for lung cancer. The successful candidate will contribute to the design, mechanistic evaluation, preclinical validation, and translational development of novel bispecificantibodies and immune-cell engagers.

We offer

The opportunity to work on an impactful translational cancer immunotherapy programme focused on next-generation bispecific therapeutics for lung cancer.

Access to advanced platforms for flow cytometry, live-cell imaging, in vivo imaging, proteomics, and translational immune profiling.

A multidisciplinary academic-clinical research environment with opportunities for scientific publication, collaboration, and clinical translation.

This is a full-time position.

Candidates with strong hands-on experience in cancer immunology, functional T-cell assays, bispecific/antibody therapeutics, or relevant in vivo tumor models are strongly encouraged to apply!

Key Responsibilities

Design, optimize, and executein vitro and in vivo studies to evaluate bispecific therapeutics for lungcancer.

Maintain and characterize lungcancer cell lines, primary tumor models and/or organoids, together with humanimmune cells such as PBMCs and T cells.

Perform functional assaysincluding tumor-cell killing, T-cell activation, proliferation, cytokinerelease, immune phenotyping, and 2D/3D co-culture studies.

Conduct multi-parameter flowcytometry, live-cell imaging, and mechanism-of-action studies; analyze andinterpret experimental data.

Support relevant mouse lungcancer models, including tumor implantation, treatment, sample collection, andbioluminescence imaging where required.

Prepare figures, reports,presentations, manuscripts, and grant-related materials; contribute to projectplanning and translational strategy.

Coordinate with internal andexternal collaborators, guide junior research staff or students whereappropriate, and support laboratory biosafety and research operations.

Key Requirements

PhD in Immunology, Cancer Biology, Biomedical Sciences, Molecular Biology, Bioengineering, or a closely related discipline.

Previous research experience in cancer immunology, antibody therapeutics, T-cell biology, or lung cancer is preferred.

Strong background or interest in tumor immunology, immune evasion, T-cell activation, and antibody- or engager-based cancer therapeutics.

Hands-on experience with mammalian cell culture, human immune cells, and functional cell-based assays.

Experience with multi-parameter flow cytometry and quantitative data analysis.

Experience with tumor cytotoxicity, T-cell activation, cytokine-release, or related immune functional assays.

Experience with mouse tumor models, in vivo imaging, recombinant proteins, antibody characterization, or bispecific/T-cell engager platforms is advantageous.

Independent, self-motivated, detail-oriented, and team-oriented, with strong scientific writing, communication, analytical, and critical-thinking skills.