Research Fellow II

Location: Singapore, Sing, SG

National Neuroscience Institute of Singapore

Research Fellow II

Job Category

Research

Posting Date

18 Oct 2026

The Neuro-Oncology Research Laboratory at National Neuroscience Institute is dedicated to elucidating the molecular underpinnings of glioblastoma (GBM) and innovating effective and precise therapeutic strategies to improve clinical outcomes. Under the scientific leadership of both A/Profs Christopher Ang Beng Ti and Carol Tang, the laboratory has established significant milestones in setting up the NNI brain tumour resource (Glioportal) comprising patient-derived cells, orthotopic xenograft mouse models and clinical material fully annotated with deep content molecular data. This aids in facilitating the transition of cutting-edge therapeutic methods from research to clinical application.

We are seeking a motivated Research Fellow to support the recently awarded Joint SingHealth-Duke Neuro-Oncology programme focusing on GBM translational research. This role offers a unique opportunity to contribute to cutting-edge cancer biology research, with the potential to directly impact therapeutic strategies for GBM patients. Expertise in cancer models especially with cell cultures, cell-based assays and animal handling is highly desirable.

Key responsibilities

Independently design, troubleshoot and execute molecular biology, cell biology and biochemical experiments

Establish and optimise functional cell-based assays

Conduct in vivo studies using orthotopic GBM mouse models

Proactively identify research opportunities, troubleshoot experimental challenges, and contribute innovative ideas to advance project objectives

Maintain accurate records, analyse data rigorously, and communicate findings clearly during team meetings and scientific discussions

Prepare and organise manuscripts and research reports for submission

Ensure adherence to ethical, biosafety and institutional guidelines

Perform other related duties incidental to the work described herein

Requirements

PhD in biomedical science, life sciences or equivalent

Prior experience in laboratory cancer research

Experience working with animal (with RCULA certification) is preferred

Familiarity with techniques like cell culture, molecular biology, quantitative real-time PCR, western blot, flow cytometry, immunofluorescence/immunohistochemistry staining, confocal microscopy and cell-based assays

Proficiency in programming languages such as Python or R and experience with bioinformatics tools and software for multi-omic analysis is a plus

Demonstrable scientific track record with good publications

Possess excellent analytical, technical and problem-solving skills

Well-organized, detail-oriented and committed to high research standards

Excellent written and verbal communication skills

Highly motivated team player with ability to work independently

Req ID

5236